Lutron Caseta Pico remotes becoming unresponsive

I've got Lutron Caseta Pico remotes all over my house, used through HA to control non-Lutron devices such as Hue lights, floor fans, and even the garage door. They have worked perfectly and consistently for years.

Lately I have noticed that several of them are not registering presses. I have to press multiple times in order for it to be picked up by HA. I'm not sure yet whether this is a Lutron Hub issue or an HA issue. I did change the batteries in one Pico but it is still happening. Is this happening to anyone else? Any ideas or suggestions?