Using esp32-S3-Box-3 without Home Assistant OS

I’m running Home Assistant in Docker on an Intel NUC with Ubuntu, it works like a charm.

Can I run and integrate all the possible features/ways of using a esp32-S3-Box-3 without actually running Home Assistant OS? All the tutorials I’m seeing seems to indicate I need my instance running HASS OS, to cater for the integrations between the two.

I assume that you want to use the esp32-S3-Box-3 with ESPHome.
I’m running esphome in a separate docker container for compiling and uploading esphome to esp32 devices. The devices work in home assistant using the esphome integration.