I haven’t tried the MQTT Eventstream myself to offer a comparison, but I’m currently doing the same thing with USB over IP following this thread: RPi as Z-Wave/ZigBee-over-IP server for Hass
Curious to see which might offer the fastest response time. I have noticed the slightest of delays with the USB over IP compared to running everything off of the same server, but hasn’t been enough for me to do anything about it 