Separate topic, but if your install is supervised on Pi OS you can move everything except the bootloader to an SSD now. I was able to follow this guide for doing so without issue. Would be nice to eliminate the SD Card completely but really just a bonus at this point, I’m effectively running everything off the SSD. Performance has improved drastically and HA is only interacting with the SSD.
There’s a thread on this and other solutions. If you are on HassOS the author later wrote up a guide for getting to a similar setup on that as well.