Hi
Short answer is yes and no 
The reason why I didn’t get it working was because it is not possible to install and configure the required packages on hassio to get a remote Z-Wave stick appliance to work. The commands suggested by @nickrout did work in that I managed to install socat but then I could not manage to configure socat and get it it work properly to connect to my remote Z-Wave “server”.
So here’s what did work:
- I backed up my hassio installation (using the snapshot feature in Home Assistant, not the Proxmox backup/snapshot feature)
- I exported the hassio snapshot to my NAS
- Stopped my hassio VM in proxmox
- Created a plain Ubuntu 20.04 VM and installed HA using their Generic Linux Install method
- Now I have a plain Linux VM so can install other required tools to get remote Z-Wave to work
- I could not succesfully get socat to work for some reason. It created a /tty/ACM0 “device” on my new HA VM but HA refused to detect that device existed. So I went with the USBIP method
- The USBIP method worked perfectly. /tty/ACM0 created and detected by HA as a Z-Wave modem. Success!!
- I then restored by HA snapshot created earlier from within HA itself
- End result: 1) HA sees the remote Z-Wave stick (running on a RPI) as a local device; 2) I don’t need to have local USB device passthrough to Proxmox; 3) this means I can do live HA (Home Assistant) migration between my two Proxmox nodes with zero downtime - so true HA (High Availability) is achieved; 4) the HA (Home Assistant) snapshot feature was amazing in compeletely restoring my system & all configuration. Given I have a fairly extensive HA install that controls every aspect of our house, it was a bit of a leap of faith and I was very happy it was a seamless restore.
Hope this helps.