No, your network is stored on the stick.
Worst case is your integration wouldn’t start because it cant ‘find’ the stick. To prevent this, just make sure you are using the by-id name (the long name, not just the short path) of the serial port that references your stick then you can move it at will…
How to locate the correct path:
Then make sure your integration is setup to use the full by-id path then restart it to verify. Once it works. Shut down the integration and move your stick.