Running on a Raspberry pi not virtual environment but here is my
configuration.yaml entry that works.
Running Hassio.
#-------------------------------------
#---- Setup Z-Wave Zigbee USB Adapter
#-------------------------------------
#Nortek/GoControl Z-Wave & Zigbee USB Adapter HUSBZB-1
zha:
usb_path: /dev/ttyUSB1
database_path: /config/zigbee.db
zwave:
usb_path: /dev/ttyUSB0