FWIW, zigpy was just bumped in 2022.7.5. Not sure if it helps folks or not. Mine have been stable since getting my ConBee II back and re-pairing the devices that fell out of the mesh.
TLDR: Never use the USB 3.0 Port and a 2.4 GHz device together even on another Raspberry Pi nearby!
Long version:
OMG! What a waste of time!
The error on my end had nothing to do with an update or anything else on that setup. It was simply a coincidence that around the same time as that update came out I added a second Raspberry Pi as a home server with an SSD on the USB 3.0 port. I placed it right next to the one with HA on it. I found in some forum that the USB3 port can interfere with 2.4 GHz signals and that’s exactly what caused the issue. I had to re-pair all devices and now everything seems to be fine again.
Thanks for the help!