This problem started when I changed plattform for the Hassio. From RaspberryPi to Docker on Ubuntu.
Could it have something to do with the Docker setup?
Did you disable uninstall modemmanager on Ubuntu. I know this is required for ZigBee stick to work on Ubuntu/HA. It might be required for your rtxrfx stick as well.
The modemmanager package will interfere with any Z-Wave or Zigbee stick and should be removed or disabled. Failure to do so will result in random failures of those integrations. For example you can disable with sudo systemctl disable ModemManager and remove with sudo apt-get purge modemmanager