HA Stopped working: Raspbian Buster 2019-07-10 / VirtualEnv

I moved to Raspbian Buster 2019-07-10.
Installed Home Assistant 0.98.3 (VirtualEnv installation).
Self-signed Certificate with with correct "cn" and valid till 2030.
Correct setting of "base_url: https://xxxxxxxxxxxx.lan".
Python for HA "Python 3.7.3".
I started to get:

2019-09-05 20:04:13 ERROR (MainThread) [homeassistant.core] Error doing job: SSL handshake failed
Traceback (most recent call last):
  File "/usr/lib/python3.7/asyncio/sslproto.py", line 625, in _on_handshake_complete
    raise handshake_exc
  File "/usr/lib/python3.7/asyncio/sslproto.py", line 189, in feed_ssldata
    self._sslobj.do_handshake()
  File "/usr/lib/python3.7/ssl.py", line 763, in do_handshake
    self._sslobj.do_handshake()
ssl.SSLError: [SSL: SSLV3_ALERT_CERTIFICATE_UNKNOWN] sslv3 alert certificate unknown (_ssl.c:1056)
2019-09-05 20:04:13 ERROR (MainThread) [homeassistant.core] Error doing job: SSL error in data received
Traceback (most recent call last):
  File "/usr/lib/python3.7/asyncio/sslproto.py", line 526, in data_received
    ssldata, appdata = self._sslpipe.feed_ssldata(data)
  File "/usr/lib/python3.7/asyncio/sslproto.py", line 189, in feed_ssldata
    self._sslobj.do_handshake()
  File "/usr/lib/python3.7/ssl.py", line 763, in do_handshake
    self._sslobj.do_handshake()
ssl.SSLError: [SSL: SSLV3_ALERT_CERTIFICATE_UNKNOWN] sslv3 alert certificate unknown (_ssl.c:1056)

and main tab is loading contentiously.
I searched forum and www and I did not find any solution.
Does anybody have same configuration working: Raspbian Buster 2019-07-10 / VirtualEnv / Home Assistant 0.98.3 ?