@Himdola Yes, if I remember correctly, the CC2531 needs to be flashed --> https://www.zigbee2mqtt.io/information/flashing_the_cc2531.html
After that it will be visible as an ordinary serial port in the device list:

So I shared com8 with netburn over tcp port 5008,
and configured zigbee2mqtt’s serial port as:
"serial": {
"port": "tcp://192.168.1.18:5008"
},
(share/zigbee2mqtt/configuration.yaml)