Home Assistant suddenly stopped working. No changes to anything at all

Hi,
HA suddenly stopped working for me. The UI still loads but all switches are disabled – TPLink and LIFX. All of a sudden. No changes made to configuration in weeks.

The LIFX and TPLink phone apps still continue to function just fine in controlling the bulbs and switches, so the devices are all definitely online.

My HA logs contain:

2021-09-20 17:42:35 WARNING (SyncWorker_0) [homeassistant.loader] We found a custom integration circadian_lighting which has not been tested by Home Assistant. This component might cause stability problems, be sure to disable it if you experience issues with Home Assistant
2021-09-20 17:42:35 WARNING (SyncWorker_1) [homeassistant.loader] We found a custom integration hacs which has not been tested by Home Assistant. This component might cause stability problems, be sure to disable it if you experience issues with Home Assistant
2021-09-20 17:42:36 WARNING (Recorder) [homeassistant.components.recorder.util] The system could not validate that the sqlite3 database at //config/home-assistant_v2.db was shutdown cleanly
2021-09-20 17:42:36 WARNING (Recorder) [homeassistant.components.recorder.util] Ended unfinished session (id=31 from 2021-09-20 07:17:53.622249)
2021-09-20 17:42:38 ERROR (SyncWorker_0) [homeassistant.components.octoprint] Failed to connect to Octoprint server. Error: HTTPConnectionPool(host='octopi.local', port=80): Max retries exceeded with url: /api/printer (Caused by NewConnectionError('<urllib3.connection.HTTPConnection object at 0x7f0c9c9648e0>: Failed to establish a new connection: [Errno -2] Name does not resolve'))
2021-09-20 17:44:40 WARNING (MainThread) [homeassistant.helpers.service] Unable to find referenced entities switch.bedroom0
2021-09-20 17:44:40 WARNING (MainThread) [homeassistant.helpers.service] Unable to find referenced entities switch.bedroom1
2021-09-20 17:44:41 WARNING (MainThread) [homeassistant.helpers.service] Unable to find referenced entities switch.bedroom0
2021-09-20 17:44:41 WARNING (MainThread) [homeassistant.helpers.service] Unable to find referenced entities switch.bedroom1
2021-09-20 17:44:42 WARNING (MainThread) [homeassistant.helpers.service] Unable to find referenced entities switch.patio_outlet
2021-09-20 17:44:43 WARNING (MainThread) [homeassistant.helpers.service] Unable to find referenced entities switch.patio_outlet
2021-09-20 17:44:44 WARNING (MainThread) [homeassistant.helpers.service] Unable to find referenced entities switch.dining
2021-09-20 17:44:45 WARNING (MainThread) [homeassistant.helpers.service] Unable to find referenced entities switch.dining

Where should I start in debugging this?