Is Home Assistant working and stable if installed on Raspian Stretch LITE after installed OpenVPN + DuckDNS NOT in HA?

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Dear All,
I just want to ask if the OS installed on Raspberry pi 3,: Raspbian Stretch LITE with installed OpenVPN (via PiVPN) + DuckDNS, is compatible and stable if I after install the Home Assistant (HASS.IO) program that remain in daemon background to control the raspberry Pi 3 GPIO…??

Thanks in advance!

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i dont see why not.
HA is just a python program.

but you shouldnt install hassio, but homeassistant. hassio is an operating system (like windows or linux)