Migration from SD to mSATA

Currently I’m running Hassio 0.88.2 from SD card. I would like use my X850 expansian card with mSATA storage as the boot-device (USB).

I made an image from the SD card and cloned it to the mSATA using Etcher.
I read a post about changing the OTP (one-time programmable) memory. It also states that “any change you make to the OTP is permanent and cannot be undone”…

Is it true that any mistake will make the RPI unusable?

Anyone with experience on this? Any tips? Do’s? Don’ts ?

Unusable? No it just means you can’t change it back to sd-card only boot