Nginx error can't connect to Upstream?

I have duckdns addon installed and Nginx proxy installed by a supervised Hass installation. I can reach my home assistant with the duckdns extern url from outside and works like a charm but i see by the Nginx Proxy Log files a lot of errors. What is it and how can i solve this?

2020/08/09 11:29:26 [error] 217#217: *4486 connect() failed (111: Connection refused) while connecting to upstream, client: {my ip adres}, server: {my duckdns adres}, request: "GET /api/websocket HTTP/1.1", upstream: "http://172.xx.xx.x:8123/api/websocket", host: "{my duckdns adres}"
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