I was hoping for some detailed help in building this automation.
I have a distiller that I want to setup, change an input boolean distiller_ready to on and have node-red create and monitor a countdown time for 4.5 hours. The countdown time must survive node-red restarts. At the end of the 4.5 hour cycle a notification is sent and the distiller_ready input boolean is turned off.
Extra credit: A homeassistant sensor and lovelace card that shows the node-red countdown timer. 
How accurate on the 4.5 hours does it have to be?
If it has to survive a restart then it could be delayed with the restart time (at least)
Timers are funny all around in HA and nodered when it comes to restarts. Setting an input_datetime I find is the best way to avoid missing a trigger. The second trigger won’t fire if the boolean is turned off by the first should it restart at trigger time.
The new time node can add time to a datetime entity. Set the entity at the current date time when the boolean turns on. you’ll need a datetime sensor set up in HA the way I have it set.
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+/- 5 to 10 minutes