Problems with different components after upgrade higher 4.3

I have HASS running on an Raspi 3. CONBEE II is connected to USB, Homematic is on a seperate Raspi. I’m using several custom integrations like VW CarNet, EUFY, Wunderground.
If I try to upgrade the environment to a newer release, nearly all devices are not reachable directly after that. If I do a rollback to 3.4 all is running fine again.

Did I miss something in the release change?

Thanks and best regards

Check out your logs and figure out what’s stopping the update.