Updating firmware on Digi XBee 3 USB Adapter (XU3-A11) that is in use

I’ve been using this USB adapter with HA for over a year now. Can I shutdown my HA host, pull the stick, update it via the XCTU software, then plug it back in and turn HA on again or is it not advisable to update the firmware once it has been used?

Thanks,

->g.