I had the same issues with my first setup. I thought using an external ssd would help with stability but little did I know this would be the source of all my woes in getting started with HA. I think there needs to be more prominent information available when setting up a HA server using usb3.
Issues I found:
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Usb3 ssd when in a low power/low speed mode doesn’t cause too much interference. Though can be unstable if not enough current is supplied the ssd. In my case I had a 3amp psu which was enough to run the ssd but only in a low power mode. This caused intermittent drop out issues.
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Usb3 when in high speed mode generates lots of noise around the 2.5ghz frequency which crosses into the 2.4ghz band causing issues with zigbee and WiFi when operating in 2.4ghz bands. Once I resolved my ssd power issues it caused almost all my radio to start intermittently fail.
As a lot of setups will be near the router and have the devices connected directly to the computer often raspberry pi, they will exacibate potentially both these issues and face lots of stability issues.
In my case using a powered hub, moving the pi and ssd as far away from any radio solved these issues.
Had I used an sd card I likely wouldn’t have had any of these issues.