This is how I was able to get the Zooz ZST10 S2 Stick to Work on HA VM running on Windows 10.
add a USB filter on the VM Settting tab with a USB filter linked to Sigma Designs. Start the VM. Then checked the supervisor>system>hardware and verified that the port /dev/ttyACM0 was present. Then I added
zwave:
usb_path: /dev/ttyACM0
to configurations.yaml
Restarted HA and was able to add a ZEN21 switch.
I may have restarted HA a few more times in between to get it running. Initially, i tried to link the com port on the HOST but that did not seem to work, nor am I a linux expert to troubleshoot.