Wireguard VPN with IPv6

I previously had a great setup using Home Assistant with the Wireguard addon to provide VPN access to my home network with the DuckDNS addon providing me with DDNS access.

However my ISP now dropped support for native IPv4 providing IPV6 with DS-Lite which my understanding means providing me with IPv4 access to the outside world through some remote NAT service to translate the IPv6 packets.

Do I have to change my LAN to support IPv6 in order to get things working again or can I leave this on IPv4.