Z-wave dongles and virtual machines

Right now I only have one Z-wave device (a Schlage lock) that I added to my ISY hub, and then exposed that to Home Assistant. Is it possible to add the lock directly to HA via the dongle? Would I then be able to make the ISY act as a secondary controller so it can see the HA z-wave devices?

And if the above is true, would I be able to plug the Z-wave dongle into a host machine running VirtualBox or Hyper-V and then expose it to a VM running HA?

I can’t answer your question regarding pairing your lock with your Z-Wave dongle, but as for the other part, yes, that is how I’m running my HASS instance; as a virtual machine in ESXi 6 with a Z-Wave dongle exposed from the host to the VM.