ZHA can't start anymore due to a: BrokenPipeError: [Errno 32] Broken pipe

I’ve got no clue what to try next. This morning HA was offline and after a reboot I got the error below. I’ve rebooted the host multiple times today with and without zigbee stick connected. Also tried different USB ports but every time the same result. Also restored from saturdays backup. Hope someone can help me. Removing the ZHA integration is the last thing I want to do since I have 30-ish devices connected trough zigbee.

Logger: homeassistant.components.zha.core.gateway
Source: components/zha/core/gateway.py:152
Integration: Zigbee Home Automation (documentation, issues)
First occurred: 10:49:48 PM (41 occurrences)
Last logged: 11:41:26 PM

Couldn't start ZNP = Texas Instruments Z-Stack ZNP protocol: CC253x, CC26x2, CC13x2 coordinator
Traceback (most recent call last):
  File "/usr/src/homeassistant/homeassistant/components/zha/core/gateway.py", line 152, in async_initialize
    self.application_controller = await app_controller_cls.new(
  File "/usr/local/lib/python3.9/site-packages/zigpy/application.py", line 69, in new
    await app.startup(auto_form)
  File "/usr/local/lib/python3.9/site-packages/zigpy_znp/zigbee/application.py", line 196, in startup
    return await self._startup(
  File "/usr/local/lib/python3.9/site-packages/zigpy_znp/zigbee/application.py", line 209, in _startup
    await znp.connect()
  File "/usr/local/lib/python3.9/site-packages/zigpy_znp/api.py", line 81, in connect
    self._uart = await uart.connect(self._config[conf.CONF_DEVICE], self)
  File "/usr/local/lib/python3.9/site-packages/zigpy_znp/uart.py", line 174, in connect
    transport.serial.dtr = False
  File "/usr/local/lib/python3.9/site-packages/serial/serialutil.py", line 473, in dtr
    self._update_dtr_state()
  File "/usr/local/lib/python3.9/site-packages/serial/serialposix.py", line 715, in _update_dtr_state
    fcntl.ioctl(self.fd, TIOCMBIC, TIOCM_DTR_str)
BrokenPipeError: [Errno 32] Broken pipe

what HA release are you on?
Do you have maybe another Zigbee integration running at the same time: Deconz, zigbee2mqtt? Ihad a similar issue while was piloting ZHA and after reboot z2m was automatically started, which I did not noticed at the beginning…

Hi Kol

I’m on the latest version, 2021.11.5. ZHA is the only zigbee related integration i’m running.