The other day my HA instance started complaining that it was unable to open the port for my ZZH stick in order to get ZHA working.
I’m running Home Assistant on the Blue and have been for months now without incident. I’ve tried to go back to my last known working backup but that hasn’t helped.
Subsequently I realised that none of the USB port were active 
This is my full setup:
System Health
version: core-2021.5.4
installation_type: Home Assistant OS
dev: false
hassio: true
docker: true
virtualenv: false
python_version: 3.8.9
os_name: Linux
os_version: 5.9.16
arch: aarch64
timezone: Europe/London
GitHub API: ok
Github API Calls Remaining: 4813
Installed Version: 1.12.3
Stage: running
Available Repositories: 899
Installed Repositories: 30
logged_in: true
subscription_expiration: 26 May 2021, 1:00
relayer_connected: true
remote_enabled: true
remote_connected: true
alexa_enabled: true
google_enabled: true
can_reach_cert_server: ok
can_reach_cloud_auth: ok
can_reach_cloud: ok
host_os: Home Assistant OS 5.13
update_channel: stable
supervisor_version: supervisor-2021.04.3
docker_version: 19.03.15
disk_total: 113.9 GB
disk_used: 15.6 GB
healthy: true
supported: true
board: odroid-n2
supervisor_api: ok
version_api: ok
installed_addons: Terminal & SSH (9.1.2), Samba share (9.4.0), SQLite Web (3.0.1), Log Viewer (0.9.1), Check Home Assistant configuration (3.7.1), Tor (3.0.2), Home Assistant Google Drive Backup (0.103.1), SSH & Web Terminal (8.0.3), Node-RED (8.1.2), Mosquitto broker (6.0.1), Visual Studio Code (3.1.0), MariaDB (2.3.0)
dashboards: 8
resources: 24
views: 30
mode: storage