My log is also strange now, I restarted several times, same log entries. CPU is now at 0%.
I unplugged en replugged the CC2531, see below the entries in the log of the hardware in HA:
22-04-01 09:40:40 INFO (MainThread) [supervisor.hardware.monitor] Detecting HardwareAction.REMOVE hardware /dev/ttyACM0 - /dev/serial/by-id/usb-Texas_Instruments_TI_CC2531_USB_CDC___0X00124B001CDD431F-if00
22-04-01 09:40:40 INFO (MainThread) [supervisor.hardware.monitor] Detecting HardwareAction.REMOVE hardware /dev/bus/usb/002/003 - None
22-04-01 09:40:49 INFO (MainThread) [supervisor.hardware.monitor] Detecting HardwareAction.ADD hardware /dev/bus/usb/002/004 - None
22-04-01 09:40:49 INFO (MainThread) [supervisor.hardware.monitor] Detecting HardwareAction.ADD hardware /dev/ttyACM0 - /dev/serial/by-id/usb-Texas_Instruments_TI_CC2531_USB_CDC___0X00124B001CDD431F-if00
Log of Zigbee2mqtt
2022-04-01T07:42:20.865Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,25,68,129,0,0,6,0,178,16,1,1,0,39,0,58,243,3,0,0,5,8,10,11,1,0,178,16,29,39]
2022-04-01T07:42:20.866Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,25,68,129,0,0,6,0,178,16,1,1,0,39,0,58,243,3,0,0,5,8,10,11,1,0,178,16,29,39]
2022-04-01T07:42:20.866Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 25 - 2 - 4 - 129 - [0,0,6,0,178,16,1,1,0,39,0,58,243,3,0,0,5,8,10,11,1,0,178,16,29] - 39
2022-04-01T07:42:20.866Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- AF - incomingMsg - {"groupid":0,"clusterid":6,"srcaddr":4274,"srcendpoint":1,"dstendpoint":1,"wasbroadcast":0,"linkquality":39,"securityuse":0,"timestamp":258874,"transseqnumber":0,"len":5,"data":{"type":"Buffer","data":[8,10,11,1,0]}}
2022-04-01T07:42:20.867Z zigbee-herdsman:controller:log Received 'zcl' data '{"frame":{"Header":{"frameControl":{"frameType":0,"manufacturerSpecific":false,"direction":1,"disableDefaultResponse":false,"reservedBits":0},"transactionSequenceNumber":10,"manufacturerCode":null,"commandIdentifier":11},"Payload":{"cmdId":1,"statusCode":0},"Command":{"ID":11,"name":"defaultRsp","parameters":[{"name":"cmdId","type":32},{"name":"statusCode","type":32}]}},"address":4274,"endpoint":1,"linkquality":39,"groupID":0}'
2022-04-01T07:42:20.868Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:20.869Z zigbee-herdsman:adapter:zStack:adapter sendZclFrameToEndpointInternal 0xbc33acfffe0e814a:21492/1 (0,0,5)
2022-04-01T07:42:20.870Z zigbee-herdsman:adapter:zStack:znp:SREQ --> AF - dataRequest - {"dstaddr":21492,"destendpoint":1,"srcendpoint":1,"clusterid":6,"transid":11,"options":0,"radius":30,"len":3,"data":{"type":"Buffer","data":[1,12,1]}}
2022-04-01T07:42:20.870Z zigbee-herdsman:adapter:zStack:unpi:writer --> frame [254,13,36,1,244,83,1,1,6,0,11,0,30,3,1,12,1,147]
2022-04-01T07:42:20.889Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,1,100,1,0,100]
2022-04-01T07:42:20.889Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,1,100,1,0,100]
2022-04-01T07:42:20.889Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 1 - 3 - 4 - 1 - [0] - 100
2022-04-01T07:42:20.890Z zigbee-herdsman:adapter:zStack:znp:SRSP <-- AF - dataRequest - {"status":0}
2022-04-01T07:42:20.890Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:20.906Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,3,68,128,0,1,11,205]
2022-04-01T07:42:20.906Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,3,68,128,0,1,11,205]
2022-04-01T07:42:20.907Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 3 - 2 - 4 - 128 - [0,1,11] - 205
2022-04-01T07:42:20.907Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- AF - dataConfirm - {"status":0,"endpoint":1,"transid":11}
2022-04-01T07:42:20.907Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:20.924Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,3,69,196,244,83,0,37]
2022-04-01T07:42:20.924Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,3,69,196,244,83,0,37]
2022-04-01T07:42:20.924Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 3 - 2 - 5 - 196 - [244,83,0] - 37
2022-04-01T07:42:20.924Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- ZDO - srcRtgInd - {"dstaddr":21492,"relaycount":0,"relaylist":[]}
2022-04-01T07:42:20.924Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:20.928Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,25,68,129,0,0,6,0,75,160,1,1,0,42,0,174,243,3,0,0,5,8,11,11,1,0,75,160,29,191]
2022-04-01T07:42:20.928Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,25,68,129,0,0,6,0,75,160,1,1,0,42,0,174,243,3,0,0,5,8,11,11,1,0,75,160,29,191]
2022-04-01T07:42:20.928Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 25 - 2 - 4 - 129 - [0,0,6,0,75,160,1,1,0,42,0,174,243,3,0,0,5,8,11,11,1,0,75,160,29] - 191
2022-04-01T07:42:20.929Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- AF - incomingMsg - {"groupid":0,"clusterid":6,"srcaddr":41035,"srcendpoint":1,"dstendpoint":1,"wasbroadcast":0,"linkquality":42,"securityuse":0,"timestamp":258990,"transseqnumber":0,"len":5,"data":{"type":"Buffer","data":[8,11,11,1,0]}}
2022-04-01T07:42:20.930Z zigbee-herdsman:controller:log Received 'zcl' data '{"frame":{"Header":{"frameControl":{"frameType":0,"manufacturerSpecific":false,"direction":1,"disableDefaultResponse":false,"reservedBits":0},"transactionSequenceNumber":11,"manufacturerCode":null,"commandIdentifier":11},"Payload":{"cmdId":1,"statusCode":0},"Command":{"ID":11,"name":"defaultRsp","parameters":[{"name":"cmdId","type":32},{"name":"statusCode","type":32}]}},"address":41035,"endpoint":1,"linkquality":42,"groupID":0}'
2022-04-01T07:42:20.930Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:20.930Z zigbee-herdsman:adapter:zStack:adapter sendZclFrameToEndpointInternal 0x14b457fffe739726:32865/1 (0,0,4)
2022-04-01T07:42:20.930Z zigbee-herdsman:adapter:zStack:znp:SREQ --> AF - dataRequest - {"dstaddr":32865,"destendpoint":1,"srcendpoint":1,"clusterid":6,"transid":12,"options":0,"radius":30,"len":3,"data":{"type":"Buffer","data":[1,13,0]}}
2022-04-01T07:42:20.930Z zigbee-herdsman:adapter:zStack:unpi:writer --> frame [254,13,36,1,97,128,1,1,6,0,12,0,30,3,1,13,0,210]
2022-04-01T07:42:20.959Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,1,100,1,0,100]
2022-04-01T07:42:20.959Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,1,100,1,0,100]
2022-04-01T07:42:20.959Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 1 - 3 - 4 - 1 - [0] - 100
2022-04-01T07:42:20.959Z zigbee-herdsman:adapter:zStack:znp:SRSP <-- AF - dataRequest - {"status":0}
2022-04-01T07:42:20.959Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:20.991Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,3,68,128,0,1,12,202]
2022-04-01T07:42:20.991Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,3,68,128,0,1,12,202]
2022-04-01T07:42:20.991Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 3 - 2 - 4 - 128 - [0,1,12] - 202
2022-04-01T07:42:20.991Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- AF - dataConfirm - {"status":0,"endpoint":1,"transid":12}
2022-04-01T07:42:20.991Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:20.998Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,25,68,129,0,0,6,0,244,83,1,1,0,47,0,117,244,3,0,0,5,8,12,11,1,0,244,83,29,97,254,3,69,196,97,128,0,99]
2022-04-01T07:42:20.998Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,25,68,129,0,0,6,0,244,83,1,1,0,47,0,117,244,3,0,0,5,8,12,11,1,0,244,83,29,97,254,3,69,196,97,128,0,99]
2022-04-01T07:42:20.998Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 25 - 2 - 4 - 129 - [0,0,6,0,244,83,1,1,0,47,0,117,244,3,0,0,5,8,12,11,1,0,244,83,29] - 97
2022-04-01T07:42:20.999Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- AF - incomingMsg - {"groupid":0,"clusterid":6,"srcaddr":21492,"srcendpoint":1,"dstendpoint":1,"wasbroadcast":0,"linkquality":47,"securityuse":0,"timestamp":259189,"transseqnumber":0,"len":5,"data":{"type":"Buffer","data":[8,12,11,1,0]}}
2022-04-01T07:42:20.999Z zigbee-herdsman:controller:log Received 'zcl' data '{"frame":{"Header":{"frameControl":{"frameType":0,"manufacturerSpecific":false,"direction":1,"disableDefaultResponse":false,"reservedBits":0},"transactionSequenceNumber":12,"manufacturerCode":null,"commandIdentifier":11},"Payload":{"cmdId":1,"statusCode":0},"Command":{"ID":11,"name":"defaultRsp","parameters":[{"name":"cmdId","type":32},{"name":"statusCode","type":32}]}},"address":21492,"endpoint":1,"linkquality":47,"groupID":0}'
2022-04-01T07:42:20.999Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,3,69,196,97,128,0,99]
2022-04-01T07:42:20.999Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 3 - 2 - 5 - 196 - [97,128,0] - 99
2022-04-01T07:42:20.999Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- ZDO - srcRtgInd - {"dstaddr":32865,"relaycount":0,"relaylist":[]}
2022-04-01T07:42:20.999Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:21.000Z zigbee-herdsman:adapter:zStack:adapter sendZclFrameToEndpointInternal 0x14b457fffe27842f:20222/1 (0,0,3)
2022-04-01T07:42:21.000Z zigbee-herdsman:adapter:zStack:znp:SREQ --> AF - dataRequest - {"dstaddr":20222,"destendpoint":1,"srcendpoint":1,"clusterid":6,"transid":13,"options":0,"radius":30,"len":3,"data":{"type":"Buffer","data":[1,14,0]}}
2022-04-01T07:42:21.000Z zigbee-herdsman:adapter:zStack:unpi:writer --> frame [254,13,36,1,254,78,1,1,6,0,13,0,30,3,1,14,0,129]
2022-04-01T07:42:21.105Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,1,100,1,0,100,254,3,68,128,0,1,13,203,254,25,68,129,0,0,6,0,97,128,1,1,0,73,0,51,245,3,0,0,5,8,13,11,0,0,97,128,29,64,254,5,69,196,254,78,1,43,43,53]
2022-04-01T07:42:21.105Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,1,100,1,0,100,254,3,68,128,0,1,13,203,254,25,68,129,0,0,6,0,97,128,1,1,0,73,0,51,245,3,0,0,5,8,13,11,0,0,97,128,29,64,254,5,69,196,254,78,1,43,43,53]
2022-04-01T07:42:21.105Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 1 - 3 - 4 - 1 - [0] - 100
2022-04-01T07:42:21.105Z zigbee-herdsman:adapter:zStack:znp:SRSP <-- AF - dataRequest - {"status":0}
2022-04-01T07:42:21.105Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,3,68,128,0,1,13,203,254,25,68,129,0,0,6,0,97,128,1,1,0,73,0,51,245,3,0,0,5,8,13,11,0,0,97,128,29,64,254,5,69,196,254,78,1,43,43,53]
2022-04-01T07:42:21.105Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 3 - 2 - 4 - 128 - [0,1,13] - 203
2022-04-01T07:42:21.105Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- AF - dataConfirm - {"status":0,"endpoint":1,"transid":13}
2022-04-01T07:42:21.106Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,25,68,129,0,0,6,0,97,128,1,1,0,73,0,51,245,3,0,0,5,8,13,11,0,0,97,128,29,64,254,5,69,196,254,78,1,43,43,53]
2022-04-01T07:42:21.106Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 25 - 2 - 4 - 129 - [0,0,6,0,97,128,1,1,0,73,0,51,245,3,0,0,5,8,13,11,0,0,97,128,29] - 64
2022-04-01T07:42:21.106Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- AF - incomingMsg - {"groupid":0,"clusterid":6,"srcaddr":32865,"srcendpoint":1,"dstendpoint":1,"wasbroadcast":0,"linkquality":73,"securityuse":0,"timestamp":259379,"transseqnumber":0,"len":5,"data":{"type":"Buffer","data":[8,13,11,0,0]}}
2022-04-01T07:42:21.106Z zigbee-herdsman:controller:log Received 'zcl' data '{"frame":{"Header":{"frameControl":{"frameType":0,"manufacturerSpecific":false,"direction":1,"disableDefaultResponse":false,"reservedBits":0},"transactionSequenceNumber":13,"manufacturerCode":null,"commandIdentifier":11},"Payload":{"cmdId":0,"statusCode":0},"Command":{"ID":11,"name":"defaultRsp","parameters":[{"name":"cmdId","type":32},{"name":"statusCode","type":32}]}},"address":32865,"endpoint":1,"linkquality":73,"groupID":0}'
2022-04-01T07:42:21.106Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,5,69,196,254,78,1,43,43,53]
2022-04-01T07:42:21.106Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 5 - 2 - 5 - 196 - [254,78,1,43,43] - 53
2022-04-01T07:42:21.106Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- ZDO - srcRtgInd - {"dstaddr":20222,"relaycount":1,"relaylist":[11051]}
2022-04-01T07:42:21.106Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:21.107Z zigbee-herdsman:adapter:zStack:adapter sendZclFrameToEndpointInternal 0x14b457fffe429017:4974/1 (0,0,2)
2022-04-01T07:42:21.107Z zigbee-herdsman:adapter:zStack:znp:SREQ --> AF - dataRequest - {"dstaddr":4974,"destendpoint":1,"srcendpoint":1,"clusterid":6,"transid":14,"options":0,"radius":30,"len":3,"data":{"type":"Buffer","data":[1,15,0]}}
2022-04-01T07:42:21.107Z zigbee-herdsman:adapter:zStack:unpi:writer --> frame [254,13,36,1,110,19,1,1,6,0,14,0,30,3,1,15,0,78]
2022-04-01T07:42:21.119Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,25,68,129,0,0,6,0,254,78,1,1,0,60,0,37,246,3,0,0,5,8,14,11,0,0,43,43,28,146]
2022-04-01T07:42:21.119Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,25,68,129,0,0,6,0,254,78,1,1,0,60,0,37,246,3,0,0,5,8,14,11,0,0,43,43,28,146]
2022-04-01T07:42:21.119Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 25 - 2 - 4 - 129 - [0,0,6,0,254,78,1,1,0,60,0,37,246,3,0,0,5,8,14,11,0,0,43,43,28] - 146
2022-04-01T07:42:21.119Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- AF - incomingMsg - {"groupid":0,"clusterid":6,"srcaddr":20222,"srcendpoint":1,"dstendpoint":1,"wasbroadcast":0,"linkquality":60,"securityuse":0,"timestamp":259621,"transseqnumber":0,"len":5,"data":{"type":"Buffer","data":[8,14,11,0,0]}}
2022-04-01T07:42:21.120Z zigbee-herdsman:controller:log Received 'zcl' data '{"frame":{"Header":{"frameControl":{"frameType":0,"manufacturerSpecific":false,"direction":1,"disableDefaultResponse":false,"reservedBits":0},"transactionSequenceNumber":14,"manufacturerCode":null,"commandIdentifier":11},"Payload":{"cmdId":0,"statusCode":0},"Command":{"ID":11,"name":"defaultRsp","parameters":[{"name":"cmdId","type":32},{"name":"statusCode","type":32}]}},"address":20222,"endpoint":1,"linkquality":60,"groupID":0}'
2022-04-01T07:42:21.120Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:21.161Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,1,100,1,0,100]
2022-04-01T07:42:21.161Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,1,100,1,0,100]
2022-04-01T07:42:21.161Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 1 - 3 - 4 - 1 - [0] - 100
2022-04-01T07:42:21.161Z zigbee-herdsman:adapter:zStack:znp:SRSP <-- AF - dataRequest - {"status":0}
2022-04-01T07:42:21.162Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:21.165Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,5,69,196,110,19,1,180,97,45]
2022-04-01T07:42:21.165Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,5,69,196,110,19,1,180,97,45]
2022-04-01T07:42:21.165Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 5 - 2 - 5 - 196 - [110,19,1,180,97] - 45
2022-04-01T07:42:21.165Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- ZDO - srcRtgInd - {"dstaddr":4974,"relaycount":1,"relaylist":[25012]}
2022-04-01T07:42:21.165Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:21.172Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,3,68,128,0,1,14,200]
2022-04-01T07:42:21.173Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,3,68,128,0,1,14,200]
2022-04-01T07:42:21.173Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 3 - 2 - 4 - 128 - [0,1,14] - 200
2022-04-01T07:42:21.173Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- AF - dataConfirm - {"status":0,"endpoint":1,"transid":14}
2022-04-01T07:42:21.173Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []
2022-04-01T07:42:21.224Z zigbee-herdsman:adapter:zStack:unpi:parser <-- [254,25,68,129,0,0,6,0,110,19,1,1,0,55,0,83,247,3,0,0,5,8,15,11,0,0,180,97,28,247]
2022-04-01T07:42:21.224Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext [254,25,68,129,0,0,6,0,110,19,1,1,0,55,0,83,247,3,0,0,5,8,15,11,0,0,180,97,28,247]
2022-04-01T07:42:21.225Z zigbee-herdsman:adapter:zStack:unpi:parser --> parsed 25 - 2 - 4 - 129 - [0,0,6,0,110,19,1,1,0,55,0,83,247,3,0,0,5,8,15,11,0,0,180,97,28] - 247
2022-04-01T07:42:21.225Z zigbee-herdsman:adapter:zStack:znp:AREQ <-- AF - incomingMsg - {"groupid":0,"clusterid":6,"srcaddr":4974,"srcendpoint":1,"dstendpoint":1,"wasbroadcast":0,"linkquality":55,"securityuse":0,"timestamp":259923,"transseqnumber":0,"len":5,"data":{"type":"Buffer","data":[8,15,11,0,0]}}
2022-04-01T07:42:21.225Z zigbee-herdsman:controller:log Received 'zcl' data '{"frame":{"Header":{"frameControl":{"frameType":0,"manufacturerSpecific":false,"direction":1,"disableDefaultResponse":false,"reservedBits":0},"transactionSequenceNumber":15,"manufacturerCode":null,"commandIdentifier":11},"Payload":{"cmdId":0,"statusCode":0},"Command":{"ID":11,"name":"defaultRsp","parameters":[{"name":"cmdId","type":32},{"name":"statusCode","type":32}]}},"address":4974,"endpoint":1,"linkquality":55,"groupID":0}'
2022-04-01T07:42:21.226Z zigbee-herdsman:adapter:zStack:unpi:parser --- parseNext []