ZWaveJS can no longer see my ZWave stick

I have Home Assistant OS running on VirtualBox on a machine running Ubuntu. ZWaveJS has been working great for a year. Today it has started to give me this error:

“Failed to open the serial port: Error: No such file or directory, cannot open /dev/ttyUSB0”

None of my devices show up anymore and the ZwaveJS integration says: “Failed to connect: Server disconnected”.

Would anyone be able to spend a few minutes helping me track down the issue? I’m not sure where to start.

Try disconnect the stick and connect it back.

This is an old thread, but in case someone else stumbles upon it, I might have the solution here.