This log is from the core Z-Wave JS add-on. It can’t lock the serial port anymore because you also have installed the Z-Wave JS UI addon, which is a huge no-no. https://www.home-assistant.io/integrations/zwave_js/#can-i-switch-between-the-official-z-wave-js-add-on-and-the-z-wave-js-ui-add-on. If you want to switch add-ons you can follow this guide, otherwise you need to stop/uninstall ZUI add-on:
For some reason you have turned on MQTT in ZUI, but have not configured it. If you are using the integration you usually don’t need MQTT. Either configure your MQTT broker to silence this message, or turn off MQTT.