The short answer is yes…
BUT, I would suggest not to do that. Z2M supports it to some extent, but it is painful.
@jamiebennett might can confirm, but the Wiser TRVs are not certified Zigbee devices. They do use the Zigbee protocol for communication, but they do not follow it according the whole standard’s requirements.
I started to experiment with the TRVs a few years ago, when I got my hand on a handful of it and a starter kit for some ridiculously cheap money.
I wrote a device handler for those TRVs for SmartThings and some other people tested it as well, but the results were a mixture. My TRVs reacted to the standard Zigbee commands, meanwhile other people with newer firmware on their TRVs had issues.
I have migrated to Z2M and used my TRVs with that setup. For me it was working again, but I talked with people with different firmware versions, that their TRVs do reset back after 2 hours to 20 Celsius.
Last winter was the time when I pulled the trigger and pulled out the Hub to control the TRVs. They work flawlessly with the Hub. I did not use the Hub before as my heating system is really complicated with floor heating, radiators and a fireplace which can heat the house as well, not just a simple gas burner. Meawhile the heater has been replaced and it is a condensation heater which supports modulation also. So no chance that I will put the Hub in use with that, but I can meanwhile control the TRVs with the standalone Hub and through HA I can also feed back information to the heater also.
All the Wiser TRVs and the Room Stat uses a manufacturer specific Zigbee cluster with proprietary communication. I did ask years ago support about it to provide some help, as if they will support integration without the Hub to other systems like SmartThings, they could sell more of their devices without the burden of their cloud infrastructure. They were not interested.
As the TRVs are not Zigbee certified, the complete control of the TRVs are going through the manufacturer specific clusters. Probably that is the reason why people were hitting this resetting temperature issue. There wasn’t enough will to reverse engineer the whole Hub-TRV communication process. (Sniff the Zigbee communication and decode how the Hub keeps the TRVs on temperature.)
At some point regarding the different firmware versions, the TRVs were not even reacting to the standard Zigbee set temperature commands either…
I played enough with them individually that I can honestly say, just use it with a Hub.
The interesting thing in the story that Schneider Electric is/used to be a Zigbee Alliance member. And they are member of the Connectivity Standards Alliance as well. Also the Matter work group. But if you search the Drayton Wiser website, the only place where Zigbee is mentioned is this article in their blog:
All documentation just states that the devices are using a 2.4Ghz frequency for communication.