Use an automation something like this (assuming it is an integration setup in the UI).
description: "Reload xxx integration @ 2am"
mode: single
trigger:
- platform: time
at: "02:00:00"
condition: []
action:
- service: homeassistant.reload_config_entry
data:
entry_id: ad7f562e4ef537e1bf858335aae4002e
The config entry id is found in config/.storage/core.config_entries for the one you want to reload.