It’s not possible with the standard KNX Integration.
Are these 2 completely separate installations with separate ETS projects?
You could change the interfaces for Routers and even have a combined installation with 2 areas. Or connect them via Knx cable.
Maybe knxd can be used to link 2 interfaces too.
You could maybe also use the xknx custom component for the second installation (this is normally for development and has its own platform name) - not really sure if that works.
Just fyi the HA knx integration doesn’t support KNX secure. So you can get Routers instead of the Interfaces that support knx-secure, but you would have to turn secure off completely.
Another way would be to use routers with secure and 1 interface without. You could then tunnel into the interface and communicate with the second area through the routers with knx-secure connection.
In both cases you will have to avoid using the same GAs for different purposes on the 2 lines.
Also Routers are quite expensive (~250€ for one) - so if it is not critical for you I would try to use two knxd instances that connect to your tunnelling interfaces and provide a multicast server.