I think the variable speed air handler is going go be what locks you into using Trane’s thermostat. It has been a while since I looked at what is available on the market for thermostats but I just did a quick search and it appears even Nest and Ecobee still do not support variable speed fans. If you are going to have other equipment, such as a whole house humidifier or an electrostatic air cleaner, then these may need proprietary communication with the thermostat depending on the model.
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